hhv-6foundation.orgHHV-6 Foundation | HHV-6 Disease Information for Patients, Clinicians, and Researchers | Apply for a

Grant 12th International Conference on HHV-6 & 7 Announced The 12th International Conference on HHV-6 & 7 will convene in Japan at the Himeji Culture and Convention Center in March 2025. Short-course foscarnet at an early stage may suppress HHV-6 reactivation following allogenic HCT Observational study suggests that an early one-week treatment at the first sign of viral reactivation may achieve clinical benefits and avoid antiviral toxicity. Herpesvirus Reactivation Common in Severe COVID-19 HHV-6 was the most common herpesvirus found when tested in nasal swabs, but EBV was the most common in plasma. High levels of HHV-6A DNA found in blood of 52% of kidney transplant patients HHV-6A was the most common virus identified, but was not linked to worse outcomes compared to other viral infections. Newsletter || Contact Us | Donate | Repository Search Navigation Home About Scientific Advisory Board Staff Contact Us Donate Patients What Is HHV-6? HHV-6A/B Testing Research Grants Repository Cart Checkout HHV-6A/B Testing List of Genes & Proteins Lab Protocols Pictorial Atlas of HHV-6 HHV-6 Antivirals Researcher FAQ Newsletter Home About Scientific Advisory Board Staff Contact Us Donate Patients What Is HHV-6? HHV-6A/B Testing Research Grants Repository Cart Checkout HHV-6A/B Testing List of Genes & Proteins Lab Protocols Pictorial Atlas of HHV-6 HHV-6 Antivirals Researcher FAQ Newsletter Choose an Article Topic All Alzheimer’s Disease Animal Models Autoimmune Disease Bell’s Palsy Cancer ciHHV-6 Cognitive Dysfunction Drug Hypersensitivity Encephalitis & Encephalopathy Epilepsy and Seizures For Clinicians Heart Disease HIV/AIDS Progression Infertility & Miscarriage Kidney Disease Latest Scientific News Liver Disease Lung Disease Multiple Sclerosis Transplant Complications Treatments - Adoptive T cell Treatments - Alternative Treatments - Antiviral Treatments - Immune Stimulant View Post Could a specific polymorphism in HHV-6B partially explain the heritability of major depression? Individuals carrying this polymorphism had a five-fold increased risk of depression and were more likely to have a family member with major depression. View Post HHV-6A infection of thyroid cancer cells induces various growth-promoting changes Oncogene activation, pro-inflammatory cytokines, genomic instability, expression of oncogenic miRNAs are induced by infection. View Post Reactivated HHV-6, CMV, adenovirus and BK virus associated with increased mortality in pediatric sepsis Odds of mortality were 2.6-3X higher in patients with detectable viral DNA; odds were even higher with multiple herpesviruses. View Post Japanese study confirms cognitive problems from post-transplant HHV-6B reactivation Those with the highest viral loads suffered deficits in verbal memory and reduced quality of life. View Post Antibodies to a protein specific to latent HHV-6B linked to ulcerative colitis flares Patients with elevated levels of antibodies to novel biomarker SITH-1 were significantly more likely to have disease activity. View Post HHV-7 found in the bronchial lavage of 6.2% of Chinese patients with severe pneumonia It is unknown whether high viral loads correlate with worse prognosis. View Post First careful characterization of rash in immunocompetent adults with HHV-7 viremia A distinctive maculopaular pattern involving the acral areas and sometimes the trunk. View Post Review: meningitis from HHV-7 appears clinically similar to that from HHV-6B, but less frequent Of 32 patients, two had ocular complications and three had cerebral venous thrombosis. View Post Adding antithymocyte globulin to post transplant cyclophosphamide prophylaxis does not increase risk of HHV-6 reactivation after haploidentical hematopoietic cell transplantation The main risk factor for HHV-6 reactivation was low absolute lymphocyte count. View Post HHV-6B IE1 inhibits DNA damage signaling pathway leading to genomic instability Results suggest a possible link between genomic instability and iciHHV-6 associated disease. View Post MS drug teriflunomide dramatically reduces antibody titers to EBV and HHV-6 Study results are consistent with a pathogenetic role for viruses in relapsing-remitting MS. View Post Synergistic role of HHV-6A U37 and heat shock proteins in viral replication Findings provide important insights that may reveal potential targets for antiviral therapy. View Post Growing evidence of rare HHV-7 associated encephalitis and seizures in the immunocompetent The clinical picture is very similar to HHV-6B encephalitis. View Post Strong Evidence Linking HHV-6B To Pneumonia in Transplant Patients Levels of mRNA transcripts indicating active infection strengthen case for pathogenic role. View Post New Evidence that HHV-6A, like EBV, May Trigger Some Cases of Multiple Sclerosis (MS) Sera drawn before vs. after onset of MS find seropositivity for HHV-6A more likely in MS. See All All Articles View Post Japanese study confirms cognitive problems from post-transplant HHV-6B reactivation Those with the highest viral loads suffered deficits in verbal memory and reduced quality of life. View Post Individuals seropositive for herpesviruses may have greater risk of dementia Large study from UK Biobank finds that people seropositive for all of these four herpesviruses—HSV-1, HHV-6, HHV-7 and VZV—have greatly increased risk of developing dementia. View Post Murine roseolovirus (MRV) infection experiments are only partially supportive of role of HHV-6A/B in Alzheimer’s disease While MRV administered peripherally led to brain infection and neuroinflammation, it did not increase Aß deposition View Post HHV-6A promotes inflammation in astrocytoma cells by dysregulating autophagy Infection increases ROS, induces ER stress and activates STAT3, NF-κB and mTOR pathways. View Post A potential mechanism by which HHV-6A infection could promote Alzheimer’s Disease HHV-6A was found to both enhance expression and inhibit degradation of amyloid precursor protein in vitro. View Post The role of HHV-6 in dysregulating autophagy HHV-6, like some other herpesviruses, dysregulates autophagy in multiple cell types, with important biological consequences. View Post HHV-6A/B in brain disease: proposed criteria for establishing causation Three top experts on HHV-6A/B teamed up to write a comprehensive review and propose criteria for establishing HHV-6A/B to MS, epilepsy and Alzheimer’s disease. View Post HHV-6A and the suppression of miR155 in Alzheimer’s pathology Dysregulation of the microRNA miR155 is associated with pathophysiological progression of Alzheimer’s disease. HHV-6A has been shown to suppress miR155. View Post Clonally expanded CD8 T cells in spinal fluid of Alzheimer’s patients suggest an adaptive immune response to pathogens Researchers at the NIH used RNA-Seq cells from skin and blood to study the underlying mechanisms in DIHS/DRESS and identified both HHV-6 and JAK-STAT pathways as potential targets. Central memory CD4+T cells were enriched with HHV-6B. View Post NINDS/NIH investigators find very little HHV-6 RNA or DNA in either Alzheimer’s or control brains A team led by Steven Jacobson, PhD at NINDS analyzed RNA-seq datasets from 901 brains, and found only 1.2% of Alzheimer’s patients and 0.4% of controls positive for HHV-6 RNA. They also found HHV-6 DNA in less than 4% of samples tested by ddPCR. View Post The debate continues over RNA-seq analysis of HHV-6A in Alzheimer’s Two groups have challenged the widely-publicized 2018 study in 2018, that found increased HHV-6A & 7 abundance and an association with clinical and pathology scores in Alzheimer’s. The topic has become the focus vigorous debate. View Post HHV-6A induces dysregulation of autophagy in neurons and astrocytoma cells, increasing beta-amyloid and tau Building on their prior work, an Italian team has shown that HHV-6A is able to induce dysregulation of autophagy in neurons and astrocytoma cells, increasing amyloid beta and tau production. View Post HHV-6A...